get_params

the output of optim i.e. the fitted model for a particular subject

named vector of the initial parameter guess

initial_params

logical TRUE/FALSE vector indicating whether the parameters A, delta, B, gamma are to be recovered. This should be c(TRUE, TRUE, TRUE, TRUE) for the biphasic model and c(FALSE, FALSE, TRUE, TRUE) for the single phase model.

free_param_index

character vector of the parameter names. This should be c("A", "delta", "B", "gamma") for the biphasic model or c("B", "gamma") for the single phase model.

param_names

list of transformation functions to be used when back-transforming the transformed parameters. Should be the inverse of the forward transformation functions.

inv_param_transform_fn

indicator value used inside the master function to indicate the subject number.

index

This function extracts all untransformed parameters from the output of optim (i.e. the fitted model).

Analyzes longitudinal data of HIV decline in patients on antiretroviral therapy using the canonical biphasic exponential decay model (pioneered, for example, by work in Perelson et al. (1997) <doi:10.1038/387188a0>; and Wu and Ding (1999) <doi:10.1111/j.0006-341X.1999.00410.x>). Model fitting and parameter estimation are performed, with additional options to calculate the time to viral suppression. Plotting and summary tools are also provided for fast assessment of model results.

get_params: Extract fitted parameters

Description

Usage

Arguments