est_overall

Estimate overall risk and vaccine efficacy.

Various semiparametric and nonparametric statistical tools for
immune correlates analysis of vaccine clinical trial data. This includes
calculation of summary statistics and estimation of risk, vaccine efficacy,
controlled effects (controlled risk and controlled vaccine efficacy), and
mediation effects (natural direct effect, natural indirect effect,
proportion mediated). See Gilbert P, Fong Y, Kenny A, and Carone, M (2022)
<doi:10.1093/biostatistics/kxac024> and Fay MP and Follmann DA (2023)
<doi:10.48550/arXiv.2208.06465>.

Avi Kenny

vaccine

Statistical Tools for Immune Correlates Analysis of Vaccine
Clinical Trial Data

est_overall function

<dl><dt>dat</dt>
<dd>A data object returned by load_data</dd>
<dt>t_0</dt>
<dd>Time point of interest</dd>
<dt>method</dt>
<dd>One of c("KM", "Cox"), corresponding to either a Kaplan-Meier
estimator ("KM") or a marginalized Cox proportional hazards model
("Cox").</dd>
<dt>risk</dt>
<dd>Boolean. If TRUE, the controlled risk (CR) curve is computed.</dd>
<dt>ve</dt>
<dd>Boolean. If TRUE, the controlled vaccine efficacy (CVE) curve is
computed.</dd></dl>

Arguments

Estimate overall risk and vaccine efficacy — est_overall

<dl>

<dt>dat</dt>
<dd>A data object returned by load_data</dd>


<dt>t_0</dt>
<dd>Time point of interest</dd>


<dt>method</dt>
<dd>One of c("KM", "Cox"), corresponding to either a Kaplan-Meier
estimator ("KM") or a marginalized Cox proportional hazards model
("Cox").</dd>


<dt>risk</dt>
<dd>Boolean. If TRUE, the controlled risk (CR) curve is computed.</dd>


<dt>ve</dt>
<dd>Boolean. If TRUE, the controlled vaccine efficacy (CVE) curve is
computed.</dd>

</dl>

est_overall: Estimate overall risk and vaccine efficacy

Description

Usage

Value

Arguments

Examples