Velocity and Accuracy of the LOg-RAnk TEst
Description
The algorithm implemented in this package was
designed to quickly estimates the distribution of the
log-rank especially for heavy unbalanced groups. VALORATE
estimates the null distribution and the p-value of the
log-rank test based on a recent formulation. For a given
number of alterations that define the size of survival
groups, the estimation involves a weighted sum of
distributions that are conditional on a co-occurrence term
where mutations and events are both present. The estimation
of conditional distributions is quite fast allowing the
analysis of large datasets in few minutes
.