Fdr.rlrt: False discovery rate estimation for massively parallel
restricted likelihood ratio tests
Description
Given a set of RLRT results and a threshold, this function outputs an estimate of the FDR (in the empirical Bayes sense of Efron, 2010) when the given threshold is used to determine which null hypotheses to reject.
threshold at which the null hypothesis is rejected.
Value
A list with elements
MoMFDR based on method of moments estimator of RLRT parameters (Greven et al., 2008).
MLFDR based on maximum likelihood estimation of RLRT parameters, as described in Greven et al. (2008).
References
Efron, B. (2010). Large-Scale Inference: Empirical Bayes Methods for Estimation, Testing, and Prediction. New York: Cambridge University Press.
Greven, S., Crainiceanu, C. M., Kuechenhoff, H., and Peters, A. (2008). Restricted likelihood ratio testing for zero variance components in linear mixed models. Journal of Computational and Graphical Statistics, 17(4), 870--891.