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wintime (version 0.2.0)

EWTR: Expected win time against reference

Description

Calculates the control group state space probabilities using a Markov model (recommended) or a Kaplan-Meier model. This function uses these probabilities to compare each participant's clinical state to a distribution of control group states.

Usage

EWTR(
  n,
  m,
  nunique,
  maxfollow,
  untimes,
  Time,
  Delta,
  dist,
  markov_ind,
  cov,
  trt
)

Value

A list containing: The estimated treatment effect from the linear regression model, the variance, and the Z-statistic.

Arguments

n

The total number of trial participants.

m

The number of events in the hierarchy.

nunique

The number of unique control group event times (returned from wintime::markov() or wintime::km()).

maxfollow

The max control group follow up time (days) (returned from wintime::markov() or wintime::km()).

untimes

A vector containing unique control group event times (days) (returned from wintime::markov() or wintime::km()).

Time

A m x n matrix of event times (days). Rows should represent events and columns should represent participants. Rows should be in increasing order of clinical severity.

Delta

A m x n matrix of event indicators Rows should represent events and columns should represent participants. Rows should be in increasing order of clinical severity.

dist

A matrix of control group state probabilities (returned from wintime::markov() or wintime::km()).

markov_ind

An indicator of the model type used (1 for Markov, 0 for Kaplan-Meier).

cov

A n x p matrix of covariate values, where p is the number of covariates.

trt

A vector of length n containing treatment arm indicators (1 for treatment, 0 for control).