This function calculates the sum of each pair's win time difference divided by the total number of pairs.

Performs an analysis of time-to-event clinical trial data using various "win time" methods,
including 'ewt', 'ewtr', 'rmt', 'max', 'wtr', 'rwtr', and 'pwt'. These methods are used to calculate and compare
treatment effects on ordered composite endpoints. The package handles event times, event indicators, and treatment
arm indicators and supports calculations on observed and resampled data. Detailed explanations of each method and
usage examples are provided in "Use of win time for ordered composite endpoints in clinical trials," by Troendle et al.
(2024)<https://pubmed.ncbi.nlm.nih.gov/38417455/>. For more information, see the package documentation or the vignette titled "Introduction to wintime."

James Troendle

wintime

Win Time Methods for Time-to-Event Data in Clinical Trials

Samuel Lawrence

PWT function

<dl><dt>n</dt>
<dd>The total number of trial participants.</dd>
<dt>n0</dt>
<dd>The number of control arm patients.</dd>
<dt>n1</dt>
<dd>The number of treatment arm patients.</dd>
<dt>m</dt>
<dd>The number of events in the hierarchy.</dd>
<dt>Time</dt>
<dd>A m x n matrix of event time (days). Rows should represent events and columns should represent participants. Event rows should
be in increasing order of clinical severity.</dd>
<dt>Delta</dt>
<dd>A m x n matrix of event indicators. Rows should represent events and columns should represent participants. Event rows
should be in increasing order of clinical severity.</dd>
<dt>tg</dt>
<dd>A numeric vector containing treatment arm indicators (1 for treatment, 0 for control).</dd>
<dt>tau</dt>
<dd>The maximum follow up time (days).</dd></dl>

Arguments

Pairwise win time — PWT

<dl>

<dt>n</dt>
<dd>The total number of trial participants.</dd>


<dt>n0</dt>
<dd>The number of control arm patients.</dd>


<dt>n1</dt>
<dd>The number of treatment arm patients.</dd>


<dt>m</dt>
<dd>The number of events in the hierarchy.</dd>


<dt>Time</dt>
<dd>A m x n matrix of event time (days). Rows should represent events and columns should represent participants. Event rows should
be in increasing order of clinical severity.</dd>


<dt>Delta</dt>
<dd>A m x n matrix of event indicators. Rows should represent events and columns should represent participants. Event rows
should be in increasing order of clinical severity.</dd>


<dt>tg</dt>
<dd>A numeric vector containing treatment arm indicators (1 for treatment, 0 for control).</dd>


<dt>tau</dt>
<dd>The maximum follow up time (days).</dd>

</dl>

PWT: Pairwise win time

Description

Usage

Value

Arguments