This is a conventional NONMEM input data format.

datasets

This is a set of minimization tools (maximum likelihood estimation and least square fitting) to solve examples in the Johan Gabrielsson and Dan Weiner's book "Pharmacokinetic and Pharmacodynamic Data Analysis - Concepts and Applications" 5th ed. (ISBN:9198299107). Examples include linear and nonlinear compartmental model, turn-over model, single or multiple dosing bolus/infusion/oral models, allometry, toxicokinetics, reversible metabolism, in-vitro/in-vivo extrapolation, enterohepatic circulation, metabolite modeling, Emax model, inhibitory model, tolerance model, oscillating response model, enantiomer interaction model, effect compartment model, drug-drug interaction model, receptor occupancy model, and rebound phenomena model.

Kyun-Seop Bae

Minimization Tool for Pharmacokinetic-Pharmacodynamic Data
Analysis

DAT function

This data frame has 5 columns with 18 time-points for the simulation.<dl>
 <dt><code>TIME</code></dt>
<dd>Time</dd> <dt><code>AMT</code></dt>
<dd>Amount given for the compartment of <code>CMT</code> column</dd> <dt><code>RATE</code></dt>
<dd>Infusion rate</dd> <dt><code>CMT</code></dt>
<dd>Compartment number, 1=gut, 2=central, 3=peripheral, etc.</dd> <dt><code>DV</code></dt>
<dd>Currently blank and not used.</dd> 
</dl>

Format

An Example of Dosing History Table — DAT

This data frame has 5 columns with 18 time-points for the simulation.<dl>
 <dt><code>TIME</code></dt>
<dd>Time</dd>

 <dt><code>AMT</code></dt>
<dd>Amount given for the compartment of <code>CMT</code> column</dd>

 <dt><code>RATE</code></dt>
<dd>Infusion rate</dd>

 <dt><code>CMT</code></dt>
<dd>Compartment number, 1=gut, 2=central, 3=peripheral, etc.</dd>

 <dt><code>DV</code></dt>
<dd>Currently blank and not used.</dd>

 
</dl>

DAT: An Example of Dosing History Table

Description

Usage

Arguments

Format

Details