SolComp2

It calculates lambdas and coefficients for two-compartment model from K10, K12, and K21.

Two-compartment

This is a set of minimization tools (maximum likelihood estimation and least square fitting) to solve examples in the Johan Gabrielsson and Dan Weiner's book "Pharmacokinetic and Pharmacodynamic Data Analysis - Concepts and Applications" 5th ed. (ISBN:9198299107). Examples include linear and nonlinear compartmental model, turn-over model, single or multiple dosing bolus/infusion/oral models, allometry, toxicokinetics, reversible metabolism, in-vitro/in-vivo extrapolation, enterohepatic circulation, metabolite modeling, Emax model, inhibitory model, tolerance model, oscillating response model, enantiomer interaction model, effect compartment model, drug-drug interaction model, receptor occupancy model, and rebound phenomena model.

Kyun-Seop Bae

Minimization Tool for Pharmacokinetic-Pharmacodynamic Data
Analysis

SolComp2 function

<dl> <dt>K10</dt>
<dd>Ke, Elimination rate constant from central compartment</dd> <dt>K12</dt>
<dd>Rate constant from the central to the peripheral compartment</dd> <dt>K21</dt>
<dd>Rate constant from the peripheral to the central compartment</dd></dl>

Arguments

Author

Get Lambdas and Coefficients of Two-compartment Model — SolComp2

<dl>

 <dt>K10</dt>
<dd>Ke, Elimination rate constant from central compartment</dd>

 <dt>K12</dt>
<dd>Rate constant from the central to the peripheral compartment</dd>

 <dt>K21</dt>
<dd>Rate constant from the peripheral to the central compartment</dd>

</dl>

SolComp2: Get Lambdas and Coefficients of Two-compartment Model

Description

Usage

Value

Arguments

Author

Details

Examples