xpose4 (version 4.5.0)

npc.coverage: Function to plot the coverage of the Numerical Predictive Check

Description

This function takes the output from the npc command in Perl Speaks NONMEM (PsN) and makes a coverage plot. A coverage plot for the NPC looks at different prediction intervals (PIs) for each data point and calculates the total number of data points in the data set lying outside of these PIs. The plot shows the relative amount of data points outside of their PI compared to the expected amount at that PI. In addition a confidence interval around these values are computed based on the simulated data.

Usage

npc.coverage(npc.info="npc_results.csv",
             main = "Default",
             main.sub=NULL,
             main.sub.cex=0.85,
             ...)

Arguments

npc.info

The results file from the npc command in PsN. for example npc_results.csv, or if the file is in a separate directory ./npc_dir1/npc_results.csv.

main

A string giving the plot title or NULL if none. "Default" creates a default title.

main.sub

Used for names above each plot when using multiple plots. Should be a vector c("Group 1","Group 2")

main.sub.cex

The size of the main.sub titles.

...

Other arguments passed to xpose.multiple.plot.default, xyplot and others. Please see these functions for more descrip

Value

• A list of plots

See Also

read.npc.vpc.results xpose.multiple.plot.default xyplot

Examples

library(xpose4)

npc.coverage()

## to read files in a directory different than the current working directory 
npc.file <- "./another_directory/npc_results.csv"
npc.coverage(npc.info=npc.file)