synergyfinder (version 0.1)

CalculateSynergy: Calculate the synergy scores for drug combinations

Description

A function to calculate the synergy scores for drug combinations using different models.

Usage

CalculateSynergy(data, method = "ZIP", correction = TRUE)

Arguments

data

a list object generated by function ReshapeData

method

a parameter to specify which models to use to calculate the synergy scores. Choices are "ZIP", "Bliss", "HSA" and "Loewe". Defaults to "ZIP".

correction

a parameter to specify if baseline correction is used or not. Defaults to TRUE.

Value

a list of the following components: a list of the following components:

References

Yadav B, Wennerberg K, Aittokallio T, Tang J. Searching for Drug Synergy in Complex Dose-Response Landscape Using an Interaction Potency Model. Computational and Structural Biotechnology Journal 2015; 13: 504-513.

Examples

data("mathews_screening_data")
data <- ReshapeData(mathews_screening_data)
scores <- CalculateSynergy(data)