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synergyfinder (version 0.1)

Calculate and Visualize Synergy Scores for Drug Combinations

Description

Efficient implementations for all the popular synergy scoring models for drug combinations, including HSA, Loewe, Bliss and ZIP and visualization of the synergy scores as either a two-dimensional or a three-dimensional interaction surface over the dose matrix.

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Version

Install

install.packages('synergyfinder')

Monthly Downloads

3

Version

0.1

License

Artistic License 2.0

Maintainer

Liye He

Last Published

August 1st, 2016

Functions in synergyfinder (0.1)

CalculateSynergy

Calculate the synergy scores for drug combinations
ZIP

Delta synergy score based on zero interaction potency (ZIP) model
BaselineCorrectionSD

Baseline correction for the dose-response matrix of drug combinations
mathews_screening_data

A high-throughput drug combination screening data
HSA

HSA synergy score based on highest single agent (HSA) model
ReshapeData

Transform the response data from the data frame format to dose-response matrixes
Loewe

Delta synergy score based on Loewe model
FittingSingleDrug

Fitting single drug dose-response curve
Bliss

Synergy score based on Bliss model
PlotDoseResponse

Visualize the drug combination dose-response data
PlotSynergy

Drug interaction landscape