NonCompart (version 0.4.7)

LogAUC: Area Under the Curve(AUC) and Area Under the first Moment Curve(AUMC) by linear-up log-down method

Description

It calculates AUC and AUMC using the linear-up log-down method

Usage

LogAUC(x, y)

Arguments

x

vector values of the independent variable, usually time

y

vector values of the dependent variable, usually concentration

Value

AUC

area under the curve

AUMC

area under the first moment curve

Details

This function returns AUC and AUMC by the linear-up log-down method.

References

1. Gabrielsson J, Weiner D. Pharmacokinetic and Pharmacodynamic Data Analysis - Concepts and Applications. 5th ed. 2016.

2. Shargel L, Yu A. Applied Biopharmaceutics and Pharmacokinetics. 7th ed. 2015.

3. Rowland M, Tozer TN. Clinical Pharmacokinetics and Pharmacodynamics - Concepts and Applications. 4th ed. 2011.

4. Gibaldi M, Perrier D. Pharmacokinetics. 2nd ed. revised and expanded. 1982.

See Also

LinAUC,AUC

Examples

# NOT RUN {
LogAUC(Theoph[Theoph$Subject==1, "Time"], Theoph[Theoph$Subject==1, "conc"])
# Compare the last line with the above
AUC(Theoph[Theoph$Subject==1, "Time"], Theoph[Theoph$Subject==1, "conc"], down="Log") 
# }