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NonCompart (version 0.4.7)

Noncompartmental Analysis for Pharmacokinetic Data

Description

Conduct a noncompartmental analysis with industrial strength. Some features are 1) Use of CDISC SDTM terms 2) Automatic or manual slope selection 3) Supporting both 'linear-up linear-down' and 'linear-up log-down' method 4) Interval(partial) AUCs with 'linear' or 'log' interpolation method * Reference: Gabrielsson J, Weiner D. Pharmacokinetic and Pharmacodynamic Data Analysis - Concepts and Applications. 5th ed. 2016. (ISBN:9198299107).

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Version

Install

install.packages('NonCompart')

Monthly Downloads

1,246

Version

0.4.7

License

GPL-3

Maintainer

Kyun-Seop Bae

Last Published

May 7th, 2020

Functions in NonCompart (0.4.7)

Internal Functions

Display CDISC standard units and multiplied factor of NCA results

Retuns a conversion factor for the amount calculation from urine concentration and volume

Table output NCA

Area Under the Curve(AUC) and Area Under the first Moment Curve(AUMC) by linear-up log-down method

NonCompart-package

Noncompartmental Analysis for Pharmacokinetic Data

Calculate Area Under the Curve (AUC) and Area Under the first Moment Curve (AUMC) in a table format

Get the Slope of regression log(y) ~ x

Interpolate y value

Area Under the Curve(AUC) and Area Under the first Moment Curve(AUMC) by linear trapezoidal method

Determine slope for the log(y) and x regression manually

Calculate interval AUC

Choose the best-fit slope for the log(y) and x regression by the criteria of adjusted R-square.