Finding association between variables of \(i^{th}\) position and \(j^{th}\) position.
In any position wise aligned sequence dataset, occurences of R=(A,G) and Y=(C, T) at each position can be explained by a standard normal variate Z based on certain threshold value.
So, an association between any two position in the datast can be obtained which will be the association beween the two standard normal variate at this two positions.
However, the two nomal variates reprsenting the occurences of R and Y are independent of each other at a given position.