Plots of the operating characteristics obtained from a CRM simulation.
# S3 method for bcrm.sim
plot(x, trajectories = FALSE, file = NULL,
threep3 = FALSE, ...)An object of class "bcrm.sim", as returned by bcrm
when conducting a simulation.
Should a summary plot of the trajectories of administered dose levels be plotted? Defaults to FALSE.
File name where the operating characteristic plot is stored, in a pdf format.
Should operating characteristics of a standard 3+3 rule-based
design be plotted alongside the bcrm design? Defaults to
FALSE.
Further arguments passed to or from other methods
This function plots the sample size distribution (if variable), the
experimentation distribution, the recommended dose distribution and the
percentage of subjects who experience the toxicity outcome (dose-limiting
toxicity). If trajectories = TRUE then summary statistics of
administered dose levels for each patient are plotted instead. If
threep3 = TRUE then the operating characteristics of the standard 3+3
design are plotted alongside those of the bcrm design (see
threep3 for more details).
Sweeting M., Mander A., Sabin T. bcrm: Bayesian Continual Reassessment Method Designs for Phase I Dose-Finding Trials. Journal of Statistical Software (2013) 54: 1--26. http://www.jstatsoft.org/article/view/v054i13