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BIGDAWG (version 1.2.6)

Case-Control Analysis of Multi-Allelic Loci

Description

Data sets and functions for chi-squared Hardy-Weinberg and case-control association tests of highly polymorphic genetic data [e.g., human leukocyte antigen (HLA) data]. Performs association tests at multiple levels of polymorphism (haplotype, locus and HLA amino-acids) as described in Pappas DJ, Marin W, Hollenbach JA, Mack SJ. 2016. 'Bridging ImmunoGenomic Data Analysis Workflow Gaps (BIGDAWG): An integrated case-control analysis pipeline.' Human Immunology, article in press. Combines rare variants to a common class to account for sparse cells in tables as described by Hollenbach JA, Mack SJ, Thomson G, Gourraud PA. 'Analytical methods for disease association studies with immunogenetic data.' Methods Mol Biol. 2012; 882:245-66.

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Install

install.packages('BIGDAWG')

Monthly Downloads

484

Version

1.2.6

License

GPL (>= 3)

Maintainer

Last Published

February 19th, 2016

Functions in BIGDAWG (1.2.6)