A small Boolean model of major components of the IGF (Insuline-like growth receptor) pathway. Through IRS, IGF activates the well-known PI3K-Akt-mTOR signalling cascade. This cascade is finally inactivated by a feedback inhibion of IRS.
The model simplifies several complex formations and cascades by representing them as single nodes and specifying time delays instead. It therefore demonstrates the usage of temporal Boolean networks in BoolNet.

Functions to reconstruct, generate, and simulate synchronous, asynchronous, probabilistic, and temporal Boolean networks. Provides also functions to analyze and visualize attractors in Boolean networks <doi:10.1093/bioinformatics/btq124>.

Hans Kestler

BoolNet

Construction, Simulation and Analysis of Boolean Networks

Christoph Müssel

Martin Hopfensitz

Dao Zhou

Armin Biere

igf function

This data set consists of a variable <code>igf</code> of class <code>SymbolicBooleanNetwork</code> with 5 genes. The class <code>SymbolicBooleanNetwork</code> is described in more detail in <code>loadNetwork</code>.

igf: Boolean model of the IGF pathway

Description

Usage

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Examples