Modified Total Aberration Index calculation takes the sum of lengths of each segment
times its segmentation mean for each sample and divides it by the sum of the
lengths of each sample.
dataframe containing following columns: Sample, Start, End, Num_Probes, Segment_Mean
segmentMean
numerical value for the minimum segment_mean cutoff/ threshold. Default is 0.2
numProbes
Number of Probes
Value
Average of lengths weighted by segmentation mean for each unique sample
Details
Modified Total Aberration Index uses all sample values instead of those in aberrant copy number state, thus does not remove the directionality from the score.
$$
Modified\ Total\ Aberration\ Index =
\frac
{\sum^{R}_{i = 1} {d_i} \cdot {\bar{y}_{S_i}}}
{\sum^{R}_{i = 1} {d_i}}
$$