CSclone (version 1.0)

l.s: Linear relation for SNVs

Description

l.s is the linear relation between B allele frequence and the proportion of SNVs mutation(PS).

Usage

l.s(cnt, cnb1, cnb2, pc = 0, ps = NULL, baf = NULL)

Arguments

cnt

is number with the total copy number after the CNAs mutation.

cnb1

is number with the B copy number of two types of periods. The first period, the proportion of CNAs mutation is more than the proportion of SNVs mutation then cnb1 is B copy number after SNVs mutation. The second period, the proportion of CNAs mutation is less than the proportion of SNVs mutation then cnb1 is B copy number between the SNVs mutation and CNAs mutation.

cnb2

is number with the B copy number of two types of periods. The first period, the proportion of CNAs mutation is less than the proportion of SNVs mutation then cnb1 is B copy number after CNAs mutation. The second period, the proportion of CNAs mutation is more than the proportion of SNVs mutation then cnb1 is B copy number between the CNAs mutation and SNVs mutation.

pc

is number with the proportion of CNAs mutation and the default is 0.

ps

is number with the proportion of SNVs mutation and the default is NULL.

baf

is number with the B allele frequence and the default is NULL.

Value

baf is number with B allele frequence(baf) if the input is given the proportion of SNVs mutation(ps).ps is number with the proportion of SNVs mutation(ps) if the input is given the B allele frequence(baf).

Details

l.s is bidirection function. The first function is given the proportion of SNVs mutation(ps) to predict the B allele frequence(baf). The second function is given the B allele frequence(baf) to predict the proportion of SNVs mutation(ps).