Detect the correlated mutations based on selection pressure
Description
CorMut provides functions for computing kaks for
individual sites or specific amino acids and detecting
correlated mutations among them. Three methods are provided for
detecting correlated mutations ,including conditional selection
pressure, mutual information and Jaccard index. The computation
consists of two steps: First, the positive selection sites are
detected; Second, the mutation correlations are computed among
the positive selection sites. Note that the first step is
optional. Meanwhile, CorMut facilitates the comparison of the
correlated mutations between two conditions by the means of
correlated mutation network.