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DelayedEffect.Design (version 1.1.3)

Sample Size and Power Calculations using the APPLE, SEPPLE, APPLE+ and SEPPLE+ Methods

Description

Provides sample size and power calculations when the treatment time-lag effect is present and the lag duration is either homogeneous across the individual subject, or varies heterogeneously from individual to individual within a certain domain and following a specific pattern. The methods used are described in Xu, Z., Zhen, B., Park, Y., & Zhu, B. (2017) .

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Version

Install

install.packages('DelayedEffect.Design')

Monthly Downloads

220

Version

1.1.3

License

GPL-2

Maintainer

Bill Wheeler

Last Published

August 21st, 2023

Functions in DelayedEffect.Design (1.1.3)

HR.APPLE

APPLE hazard ratio computation
pow.APPLE.plus

APPLE+ power computation
pow.SEPPLE

SEPPLE power computation
DelayedEffect.Design

Sample size and power calculations using the APPLE, SEPPLE, APPLE+ and SEPPLE+ methods
pow.APPLE

APPLE power computation
pow.SEPPLE.plus

SEPPLE+ power computation
N.APPLE

APPLE sample size computation
pow.SEPPLE.random.DE

SEPPLE+ power computation
pow.sim.logrk

Simulated log-rank power computation
pow.sim.logrk.random.DE

Simulated log-rank power computation
N.APPLE.plus

APPLE+ sample size computation
HR.APPLE.plus

APPLE+ hazard ratio computation
data

Data for examples
GPW.logrank

Generalized Piecewise Weighted Logrank Test