Expression matrix, genes on rows and samples on columns
metric
Character string specifying the metric to be used for calculating dissimilarities between the columns of the matrix. This must be one of 'euclidean', 'manhattan', 'pearson', 'pearsonabs', 'spearman', 'spearmanabs', 'jaccard', 'dice'
method
Character string defining the clustering method. This
must be one of 'average', 'single', 'complete', 'ward'
nb
The number of classes for kmeans and PAM clustering (kcentroids)
Value
An object of class 'agnes' representing the clustering. See 'agnes.object' for details.
describe
average:The distance between two clusters is the average of the dissimilarities between the points in one cluster and the points in the other cluster.
single:we use the smallest dissimilarity between a point in the first cluster and a point in the second cluster (nearest neighbor method).
complete:we use the largest dissimilarity between a point in the first cluster and a point in the second cluster
ward:Ward's agglomerative method
weighted:The weighted distance from the agnes package
diana:computes a divise clustering
kcentroids:Perform either kmeans clustering if the distance is
euclidean or PAM clustering. The number of classes nb has to be done.
Details
Available metrics are (written for two vectors x and y):
[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
References
Kaufman, L. and Rousseeuw, P.J. (1990). Finding Groups in Data: An Introduction to Cluster Analysis. Wiley, New York.