pdlt

Generating probabiity of DLT based on the EWOC 2 drugs combination model

Implements Escalation With Overdose Control trial designs using two drug combinations described by this paper <doi:10.1002/sim.6961>(Tighiouart et al., 2016). It calculates the recommended dose for next cohorts and perform simulations to obtain operating characteristics.

Yujie Cui 

EWOC.Comb

Escalation with Overdose Control using 2 Drug Combinations

Quanlin Li 

Mourad Tighiouart 

pdlt function

<dl> <dt>rho00</dt>
<dd>a numeric value indicating the true value of the parameter rho00, the probability of DLT when the levels of drugs A and B are both 0</dd> <dt>rho01</dt>
<dd>a numeric value indicating the true value of the parameter rho01, the probability of DLT when the levels of drugs A and B are 0 and 1, respectively</dd> <dt>rho10</dt>
<dd>a numeric value indicating the true value of the parameter rho10, the probability of DLT when the levels of drugs A and B are 1 and 0, respectively</dd> <dt>eta</dt>
<dd>a numeric value indicating the true value of the eta, the interaction parameter</dd> <dt>theta</dt>
<dd>a numerical value defining the proportion of expected patients to experience a medically unacceptable, dose-limiting toxicity (DLT) if administered the MTD</dd> <dt>x</dt>
<dd>a numeric value of dose level for drug A</dd> <dt>y</dt>
<dd>a numeric value of dose level for drug B</dd></dl>

Arguments

Generating probability of DLT based on the EWOC2 model — pdlt

<dl>

 <dt>rho00</dt>
<dd>a numeric value indicating the true value of the parameter rho00, the probability of DLT when the levels of drugs A and B are both 0</dd>

 <dt>rho01</dt>
<dd>a numeric value indicating the true value of the parameter rho01, the probability of DLT when the levels of drugs A and B are 0 and 1, respectively</dd>

 <dt>rho10</dt>
<dd>a numeric value indicating the true value of the parameter rho10, the probability of DLT when the levels of drugs A and B are 1 and 0, respectively</dd>

 <dt>eta</dt>
<dd>a numeric value indicating the true value of the eta, the interaction parameter</dd>

 <dt>theta</dt>
<dd>a numerical value defining the proportion of expected patients to experience a medically unacceptable, dose-limiting toxicity (DLT) if administered the MTD</dd>

 <dt>x</dt>
<dd>a numeric value of dose level for drug A</dd>

 <dt>y</dt>
<dd>a numeric value of dose level for drug B</dd>

</dl>

pdlt: Generating probability of DLT based on the EWOC2 model

Description

Usage

Value

Arguments

Examples