Genomic Mediation Analysis with Adaptive Confounding Adjustment
Description
Performs genomic mediation
analysis with adaptive confounding adjustment (GMAC) proposed by Yang et al. (2017) . It implements large scale
mediation analysis and adaptively selects potential confounding variables to
adjust for each mediation test from a pool of candidate confounders. The package
is tailored for but not limited to genomic mediation analysis (e.g., cis-gene
mediating trans-gene regulation pattern where an eQTL, its cis-linking gene
transcript, and its trans-gene transcript play the roles as treatment, mediator
and the outcome, respectively), restricting to scenarios with the presence of
cis-association (i.e., treatment-mediator association) and random eQTL (i.e.,
treatment).