There are two mapping methods supported by current version. "direct" only works between human and mouse because most of human gene symbols are capitalized and only the first letter is uppercase for those homogenes in mouse. Another way is by means of package "biomaRt" ,which contains more information while the network connection is necessary to access biomaRt online server.
References
Feng, G., Du, P., Krett, N., Tessel, M., Rosen, S., Kibbe, W.A. and Lin, S.M., 'A collection of bioconductor methods to visualize gene-list annotations', BMC Research Notes 2010, 3:10