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HybridDesign (version 1.0)

Hybrid Design for Phase I Dose-Finding Studies

Description

The Hybrid design is a combination of model-assisted design (e.g., the modified Toxicity Probability Interval design) with dose-toxicity model-based design for phase I dose-finding studies. The hybrid design controls the overdosing toxicity well and leads to a recommended dose closer to the true maximum tolerated dose (MTD) due to its ability to calibrate for an intermediate dose. More details can be found in Liao et al. 2022 .

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Version

Install

install.packages('HybridDesign')

Monthly Downloads

166

Version

1.0

License

GPL-3

Maintainer

Heng Zhou

Last Published

December 15th, 2022

Functions in HybridDesign (1.0)

get_boundary_mtpi

Generate modified mTPI Design Decision Boundary
get_oc_hybrid

Generate operating characteristics for single-agent dose-finding studies using the Hybrid design
hybrid_MTD_selection

Select the maximum tolerated dose (MTD) for single-agent dose-finding studies
hybrid

Implement Hybrid design with real data