hybrid_MTD_selection

Select the maximum tolerated dose (MTD) when the single-agent dose-finding study is completed

The Hybrid design is a combination of model-assisted design (e.g., the modified
Toxicity Probability Interval design) with dose-toxicity model-based design for
phase I dose-finding studies. The hybrid design controls the overdosing
toxicity well and leads to a recommended dose closer to the true maximum tolerated
dose (MTD) due to its ability to calibrate for an intermediate dose. More details
can be found in Liao et al. 2022 <doi:10.1002/ijc.34203>.

Heng Zhou

HybridDesign

Hybrid Design for Phase I Dose-Finding Studies

Feng Zhou

Jason Liao

hybrid_MTD_selection function

<dl><dt>target</dt>
<dd>the target toxicity rate</dd>
<dt>dose</dt>
<dd>a vector containing the numerical dosage of each dose level</dd>
<dt>npts</dt>
<dd>a vector containing the number of patients treated at each dose level</dd>
<dt>nDLT</dt>
<dd>a vector containing the number of patients who experienced dose-limiting
toxicity at each dose level</dd>
<dt>elimdose</dt>
<dd>the dosage at the dose level which is excluded due to excessive toxicity</dd></dl>

Arguments

Select the maximum tolerated dose (MTD) for single-agent dose-finding studies — hybrid_MTD_selection

<dl>

<dt>target</dt>
<dd>the target toxicity rate</dd>


<dt>dose</dt>
<dd>a vector containing the numerical dosage of each dose level</dd>


<dt>npts</dt>
<dd>a vector containing the number of patients treated at each dose level</dd>


<dt>nDLT</dt>
<dd>a vector containing the number of patients who experienced dose-limiting
toxicity at each dose level</dd>


<dt>elimdose</dt>
<dd>the dosage at the dose level which is excluded due to excessive toxicity</dd>

</dl>

hybrid_MTD_selection: Select the maximum tolerated dose (MTD) for single-agent dose-finding studies

Description

Usage

Value

Arguments

Details

Examples