varU.example

An example of calculating U and V for MTAR given the summary statistics and its variance.

datasets

Perform multi-trait rare-variant association tests using the summary statistics and adjust for possible sample overlap. Package is based on "Multi-Trait Analysis of Rare-Variant Association Summary Statistics using MTAR" by Luo, L., Shen, J., Zhang, H., Chhibber, A. Mehrotra, D.V., Tang, Z., 2019 (submitted).

Lan Luo

MTAR

Multi-Trait Analysis of Rare-Variant Association Study

varU.example function

A list with 3 sublists:<dl class="dl-horizontal">
 <dt>U</dt><dd>a list of summary statistics, each sublist is \(m \times K\) matrix for each study</dd>
 <dt>varU</dt><dd>a list of variance of summary statistics, each sublist is \(m \times K\) matrix for each study</dd>
 <dt>R</dt><dd>a SNP correlation matrix for the union of SNPs appearing in all the studies</dd></dl>

Format

Example2: the summary statistics and their variance — varU.example

A list with 3 sublists:<dl class='dl-horizontal'>
 <dt>U</dt><dd>a list of summary statistics, each sublist is \(m \times K\) matrix for each study</dd>
 <dt>varU</dt><dd>a list of variance of summary statistics, each sublist is \(m \times K\) matrix for each study</dd>
 <dt>R</dt><dd>a SNP correlation matrix for the union of SNPs appearing in all the studies</dd></dl>

varU.example: Example2: the summary statistics and their variance

Description

Usage

Arguments

Format