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MTAR (version 0.1.1)

Multi-Trait Analysis of Rare-Variant Association Study

Description

Perform multi-trait rare-variant association tests using the summary statistics and adjust for possible sample overlap. Package is based on "Multi-Trait Analysis of Rare-Variant Association Summary Statistics using MTAR" by Luo, L., Shen, J., Zhang, H., Chhibber, A. Mehrotra, D.V., Tang, Z., 2019 (submitted).

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Version

Install

install.packages('MTAR')

Monthly Downloads

113

Version

0.1.1

License

GPL (>= 2)

Maintainer

Lan Luo

Last Published

April 22nd, 2020

Functions in MTAR (0.1.1)

rawdata

Example1: individual-level data
beta.example

Example3: the genetic effect estimates and their standard errors
MTAR

Multiple-Traits Analysis of Rare-Variant Association Test
Get_zeta

Calculate Covariances of Z-scores between Traits from Overlapping Samples
Get_UV_from_varU

Compute the summary statistics given the score statistics and their variance.
MTAR.example

PNPLA2 Gene
Get_UV_from_beta

Compute the summary statistics given the genetic effect estimates and their standard errors
Get_UV_from_data

Compute the summary statistics given the individual-level data
varU.example

Example2: the summary statistics and their variance
zeta.example

Example4: the summary statistics of 737 common and null SNPs