NMTox (version 0.1.0)

IsoPlot.nm: Create a plot of the observations, sample means and fitted isotonic regression curve for one nanomaterial

Description

This function generates a dose-response plot (scatter plot) of the observations, sample means and fitted isotonic regression curve for one nanomaterial

Usage

IsoPlot.nm(data.nm, dose, response, type = c("continuous", "ordinal"),
  add.curve = TRUE, nano.cat = NULL, xlabel="Dose", ylabel="Response")

Value

This function produces a plot of the observations, sample means and fitted isotonic regression curve for one nanomaterial

Arguments

data.nm

Dataset of a particular nanomaterial

dose

Dose or concentration (with the same unit of measurement)

response

Response (a certain endpoint value)

type

Type of the dose

add.curve

Adding curve to the plot

nano.cat

Title of the plot (referring to the name of the nanomaterial)

xlabel

label for the x-axis of the plot

ylabel

label for the y-axis of the plot

Details

This function is intended to be used inside the function Isoplot. However, it can also be used to generate a plot for one nanomaterial, with a particular unit of measurement of the dose and for a certain toxicity endpoint.

References

Lin D., Pramana, S., Verbeke, T., and Shkedy, Z. (2015). IsoGene: Order-Restricted Inference for Microarray Experiments. R package version 1.0-24. https://CRAN.R-project.org/package=IsoGene

Lin D., Shkedy Z., Yekutieli D., Amaratunga D., and Bijnens, L. (editors). (2012) Modeling Doseresponse Microarray Data in Early Drug Development Experiments Using R. Springer.

Examples

#nm400 contains the result of genetic toxicity in vitro study of NM-400
#(Multi-walled carbon nanotubes) with associated controls
IsoPlot.nm(data.nm=nm400, dose="concentration", response="value",
           nano.cat="Multi-walled carbon nanotubes", xlabel="Concentration",
           ylabel="DNA STRAND BREAKS")