Learn R Programming

NMTox (version 0.1.0)

Dose-Response Relationship Analysis of Nanomaterial Toxicity

Description

Perform an exploration and a preliminary analysis on the dose- response relationship of nanomaterial toxicity. Several functions are provided for data exploration, including functions for creating a subset of dataset, frequency tables and plots. Inference for order restricted dose- response data is performed by testing the significance of monotonic dose-response relationship, using Williams, Marcus, M, Modified M and Likelihood ratio tests. Several methods of multiplicity adjustment are also provided. Description of the methods can be found in .

Copy Link

Version

Install

install.packages('NMTox')

Monthly Downloads

175

Version

0.1.0

License

GPL-3

Maintainer

Rahmasari Nur Azizah

Last Published

September 1st, 2022

Functions in NMTox (0.1.0)

FrCtrl

Create a frequency table of the control values
Frtab

Generate the number of unique values, the list of unique values, or the number of observations of specified variable(s)
nmplot.ncat

Create plots of the dose and the response differentiated by specified variables
nmplot.cat

Create plots of the dose and the response grouped by a variable
nmplot.n

Create plots of the dose and the response for every unique value of a certain variable
geninvitro

Genetic toxicity in vitro dataset
adjPlot

Plot the adjusted p-values, raw p-values and FDR level
nm400

NM-400 in vitro dataset
nmplot

Create plots of the dose and the response for each nanomaterial in the dataset
IsoTest.nm

Calculate the value of the test statistics for testing monotonic trend
IsoPval.nm

Calculate p-values based on permutation for both increasing and decreasing ordered alternatives
SplitData

Split the data of each nanomaterial into different subsets of data
SubsetData

Create a subset of data
Frtab.sub

Count the number of observations for each unique value of a variable on a subset of data
Isoplot

Create plot(s) of the observations, the sample means and the fitted isotonic regression curve
Isotest

Calculate the test statistics and p-values for testing monotonic trend
IsoPlot.nm

Create a plot of the observations, sample means and fitted isotonic regression curve for one nanomaterial