NMTox (version 0.1.0)

IsoTest.nm: Calculate the value of the test statistics for testing monotonic trend

Description

This function provides the value of the test statistics (the global likelihood test, Williams, Marcus, M or modified M test) for one nanomaterial

Usage

IsoTest.nm(data.nm, dose, response, stat=c("E2", "Williams","Marcus",
  "M", "ModM"))

Value

This function calculates the value of the specified test statistics for one nanomaterial

Arguments

data.nm

Nanomaterial dataset

dose

Dose or concentration (with the same unit of measurement)

response

Response (a certain endpoint value)

stat

Test statistics ("E2" for the global likelihood test, "Williams" for Williams test, "Marcus" for Marcus test, "M" for M test or "ModM" for modified M test)

Details

This function is intended to be used inside the function Isotest. However, it can also be used to obtain the value of a specified test statistics for one nanomaterial, with a particular unit of measurement of the dose, for a certain toxicity endpoint.

References

Lin D., Pramana, S., Verbeke, T., and Shkedy, Z. (2015). IsoGene: Order-Restricted Inference for Microarray Experiments. R package version 1.0-24. https://CRAN.R-project.org/package=IsoGene

Lin D., Shkedy Z., Yekutieli D., Amaratunga D., and Bijnens, L. (editors). (2012) Modeling Doseresponse Microarray Data in Early Drug Development Experiments Using R. Springer.

See Also

Isotest

Examples

#nm400 contains the result of genetic toxicity in vitro study of NM-400
#(Multi-walled carbon nanotubes) with associated controls
IsoTest.nm(data.nm=nm400, dose="concentration", response="value", stat="E2")