NonCompart (version 0.2.4)

IndiNCA: Noncompartmental Analysis for an Individual

Description

It performs a noncompartmental analysis with one subject data

Usage

IndiNCA(x, y, Dose = 0, Method = "Linear", AdmMode = "Extravascular", TimeInfusion = 0, RetNames, Report = "Table", iAUC)

Arguments

x

vector values of independent variable, usually time

y

vector values of dependent variable, usually concentration

Dose

administered dose for the subject

Method

either of "Linear" or "Log" to indicate the way to calculate AUC and AUMC

AdmMode

one of "Bolus" or "Infusion" or "Extravascular" to indicate drug administration mode

TimeInfusion

infusion duration for constant infusion, otherwise 0

RetNames

character vector for the pharmacokinetic parameter names to be returned

Report

either of "Table" or "Text" to specify the type of return value

iAUC

data.frame with three columns, "Name", "Start", "End" to specify the invervals for partial (interval) AUC

Value

Details

This performs a noncompartmental analysis for a subject. It returns practically the same result with the most popular commercial software.

References

1. Gabrielsson J, Weiner D. Pharmacokinetic and Pharmacodynamic Data Analysis - Concepts and Applications. 5th ed. 2016.
2. Shargel L, Yu A. Applied Biopharmaceutics and Pharmacokinetics. 7th ed. 2015.
3. Rowland M, Tozer TN. Clinical Pharmacokinetics and Pharmacodynamics - Concepts and Applications. 4th ed. 2011.
4. Gibaldi M, Perrier D. Pharmacokinetics. 2nd ed. revised and expanded. 1982.

See Also

AUC, BestSlope

Examples

IndiNCA(Theoph[Theoph$Subject==1,"Time"], Theoph[Theoph$Subject==1, "conc"], Dose=320)
IndiNCA(Indometh[Indometh$Subject==1,"time"], Indometh[Indometh$Subject==1, "conc"], Dose=25,
        AdmMode="Bolus")
IndiNCA(Indometh[Indometh$Subject==1,"time"], Indometh[Indometh$Subject==1, "conc"], Dose=25,
        AdmMode="Infusion", TimeInfusion=0.25)

IndiNCA(Theoph[Theoph$Subject==1,"Time"], Theoph[Theoph$Subject==1, "conc"], Dose=320,
        Report="Text")
IndiNCA(Indometh[Indometh$Subject==1,"time"], Indometh[Indometh$Subject==1, "conc"], Dose=25,
        AdmMode="Bolus", Report="Text")
IndiNCA(Indometh[Indometh$Subject==1,"time"], Indometh[Indometh$Subject==1, "conc"], Dose=25,
        AdmMode="Infusion", TimeInfusion=0.25, Report="Text")

iAUC = data.frame(Name=c("AUC[0-12h]","AUC[0-24h]"), Start=c(0,0), End=c(12,24)) ; iAUC
IndiNCA(Theoph[Theoph$Subject==1,"Time"], Theoph[Theoph$Subject==1, "conc"], Dose=320,
        iAUC=iAUC)
IndiNCA(Indometh[Indometh$Subject==1,"time"], Indometh[Indometh$Subject==1, "conc"], Dose=25,
        AdmMode="Bolus", iAUC=iAUC)
IndiNCA(Indometh[Indometh$Subject==1,"time"], Indometh[Indometh$Subject==1, "conc"], Dose=25,
        AdmMode="Infusion", TimeInfusion=0.25, iAUC=iAUC)