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NonCompart (version 0.2.4)

Noncompartmental Analysis for Pharmacokinetic Data

Description

Conduct a noncompartmental analysis as closely as possible to the most widely used commercial software for pharmacokinetic analysis, i.e. 'Phoenix(R) WinNonlin(R)' . Some features include: - Use CDISC SDTM PP domain terms. - Automatic slope selection with the same criterion of WinNonlin(R) - Support both 'linear-up linear-down' and 'linear-up log-down' method - Calculate partial(interval) AUC with 'linear' or 'log' interpolation method For more details on noncompartmental analysis, see the reference: Gabrielsson J, Weiner D. Pharmacokinetic and Pharmacodynamic Data Analysis - Concepts and Applications. 5th ed. 2016. (ISBN:9198299107) Acknowldegement: Author thanks for the careful review and valuable input of Dr. Jee Eun Lee.

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Version

Install

install.packages('NonCompart')

Monthly Downloads

893

Version

0.2.4

License

GPL-3

Maintainer

Kyun-Seop Bae

Last Published

December 8th, 2016

Functions in NonCompart (0.2.4)

IntAUC

Calculate interval AUC
Round

Round Half Away from Zero
NonCompart-package

Noncompartmental Analysis for Pharmacokinetic Data
BestSlope

Choose best fit slope for the log(y) and x regression by the criteria of adjusted R-square
LogAUC

Area Under the Curve(AUC) and Area Under the first Moment Curve(AUMC) by linear-up log-down method
NCA

Noncompartmental analysis for a dataset with multiple subjects
AUC

Calculate Area Under the Curve (AUC) and Area Under the first Moment Curve (AUMC) in a table format
LinAUC

Area Under the Curve(AUC) and Area Under the first Moment Curve(AUMC) by linear trapezoidal method
IndiNCA

Noncompartmental Analysis for an Individual
Interpol

Interpolate y value
RptCfg

NCA Report Configuation Table
Slope

Get the Slope of regression log(y) ~ x