NonCompart (version 0.2.4)

NCA: Noncompartmental analysis for a dataset with multiple subjects

Description

conduct noncompartmental analysis for many subjects in a data table

Usage

NCA(Data, colSubj, colTime, colConc, colTrt, Method = "Linear", Dose = 0,  AdmMode = "Extravascular", TimeInfusion = 0, Report = "Table", iAUC)

Arguments

Data

name of data table containing time-concentration data of multiple subjects

colSubj

column name for subject ID

colTime

column name for the time

colConc

column name for the concentration

colTrt

column name for the treatment code. This is useful for crossover study like bioequivalence trial.

Method

one of "Linear" or "Log" to indicate the way to calculate AUC

Dose

administered dose. One should be careful for the unit. This can be a vector containing dose for each subject in order.

AdmMode

one of "Bolus" or "Infusion" or "Extravascular" to indicate drug administration mode

TimeInfusion

infusion duration for constant infusion, otherwise 0. This can be a vector containing values for each subject in order.

Report

either of "Table" or "Text" to specify the type of return value

iAUC

data.frame with three columns, "Name", "Start", "End" to specify partial interval AUC

Value

Details

This function calls IndiNCA repeatedly to do NCA for each subject. If you specify Report="Text", this function returns in free text format to be used in a report file.

References

1. Gabrielsson J, Weiner D. Pharmacokinetic and Pharmacodynamic Data Analysis - Concepts and Applications. 5th ed. 2016.
2. Shargel L, Yu A. Applied Biopharmaceutics and Pharmacokinetics. 7th ed. 2015.
3. Rowland M, Tozer TN. Clinical Pharmacokinetics and Pharmacodynamics - Concepts and Applications. 4th ed. 2011.
4. Gibaldi M, Perrier D. Pharmacokinetics. 2nd ed. revised and expanded. 1982.

See Also

IndiNCA

Examples

# Theoph and Indometh data: dose in mg, conc in mg/L, time in h
NCA(Theoph, "Subject", "Time", "conc", Dose=320)
NCA(Indometh, "Subject", "time", "conc", Dose=25, AdmMode="Bolus")

iAUC = data.frame(Name=c("AUC[0-12h]","AUC[0-24h]"), Start=c(0,0), End=c(12,24)) ; iAUC
NCA(Theoph, "Subject", "Time", "conc", Dose=320, iAUC=iAUC)
NCA(Indometh, "Subject", "time", "conc", Dose=25, AdmMode="Bolus", iAUC=iAUC)

writeLines(NCA(Theoph, "Subject", "Time", "conc", Dose=320, Report="Text"),
           "Theoph_Linear_CoreOutput.txt")
writeLines(NCA(Theoph, "Subject", "Time", "conc", Dose=320, Method="Log", Report="Text"),
           "Theoph_Log_CoreOutput.txt")
writeLines(NCA(Indometh, "Subject", "time", "conc", Dose=25, AdmMode="Bolus", Report="Text"),
           "Indometh_Bolus_Linear_CoreOutput.txt")
writeLines(NCA(Indometh, "Subject", "time", "conc", Dose=25, AdmMode="Bolus", Method="Log",
           Report="Text"), "Indometh_Bolus_Log_CoreOutput.txt")
writeLines(NCA(Indometh, "Subject", "time", "conc", Dose=25, AdmMode="Infusion", TimeInfusion=0.25,
           Report="Text"), "Indometh_Infusion_Linear_CoreOutput.txt")
writeLines(NCA(Indometh, "Subject", "time", "conc", Dose=25, AdmMode="Infusion", TimeInfusion=0.25,
           Method="Log", Report="Text"), "Indometh_Infusion_Log_CoreOutput.txt")