NonCompart (version 0.4.7)

NonCompart-package: Noncompartmental Analysis for Pharmacokinetic Data

Description

It conducts a noncompartmental analysis(NCA) with industrial strength.

Details

The main functions are

tblNCA   to perform NCA for many subjects.
sNCA     to perform NCA for one subject.

References

1. Gabrielsson J, Weiner D. Pharmacokinetic and Pharmacodynamic Data Analysis - Concepts and Applications. 5th ed. 2016.

2. Shargel L, Yu A. Applied Biopharmaceutics and Pharmacokinetics. 7th ed. 2015.

3. Rowland M, Tozer TN. Clinical Pharmacokinetics and Pharmacodynamics - Concepts and Applications. 4th ed. 2011.

4. Gibaldi M, Perrier D. Pharmacokinetics. 2nd ed. revised and expanded. 1982.

Examples

# NOT RUN {
# Theoph and Indometh data: dose in mg, conc in mg/L, time in h
tblNCA(Theoph, key="Subject", colTime="Time", colConc="conc", dose=320,
       adm="Extravascular", doseUnit="mg", concUnit="mg/L")

tblNCA(Indometh, key="Subject", colTime="time", colConc="conc", dose=25, 
       adm="Infusion", dur=0.5, doseUnit="mg", concUnit="mg/L", R2ADJ=0.9)

# For individual NCA
iAUC = data.frame(Name=c("AUC[0-12h]","AUC[0-24h]"), Start=c(0,0), End=c(12,24)) ; iAUC

x = Theoph[Theoph$Subject=="1","Time"]
y = Theoph[Theoph$Subject=="1","conc"]

sNCA(x, y, dose=320, doseUnit="mg", concUnit="mg/L", timeUnit="h", iAUC=iAUC)
sNCA(x, y, dose=320, concUnit="mg/L", iAUC=iAUC)
# }