OGSA-package

OGSA


The package applies three versions of outlier statistics across multiple molecular
data types to create a single estimate at the gene level for the number of outliers 
relative to normal controls.  These gene estimates are used in gene set analysis to 
determine deregulated pathways.  Visualization of outlier calls provide sample 
specific information on potential drivers of the gene set statistic.


OGSA provides a global estimate of pathway deregulation in
cancer subtypes by integrating the estimates of significance
for individual pathway members that have been identified by
outlier analysis.

Michael F Ochs

Outlier Gene Set Analysis

OGSA-package function

The package applies three versions of outlier statistics across multiple molecular
data types to create a single estimate at the gene level for the number of outliers 
relative to normal controls.  These gene estimates are used in gene set analysis to 
determine deregulated pathways.  Visualization of outlier calls provide sample 
specific information on potential drivers of the gene set statistic.

OGSA-package: This package uses outlier statistics and gene set analysis to identify deregulated pathways.

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