Opt5PL (version 0.1.1)

c_weight_2: The second derivative of the c-optimality criterion with respect to the model parameters

Description

The second derivative of the c-optimality criterion with respect to the model parameters. This is a sub-function of c_weight to run one iteration of Newton-Raphson method.

Usage

c_weight_2(W, T, X, inv, p, order)

Arguments

W

A numeric vector. The first K-1 weights for a given design

T

A numeric vector. Model parameter values

X

A numeric vector. K dose levels for a given design

inv

A numeric matrix. Inverse of the information matrix.

p

A numeric. Define EDp

order

numeric. The number of model paraemters