OneComp_Volume_Clearance

<p>The volume of distribution of compartment 1</p>

V1.sd

Cl1.sd

covar

<p>Calculate pharmacokinetic parameters with volume of distribution (V1) and
clearance (Cl1)</p>

Pharmacokinetics is the study of drug absorption, distribution,
metabolism, and excretion. The pharmacokinetics model explains that how the
drug concentration change as the drug moves through the different compartments
of the body. For pharmacokinetic modeling and analysis, it is essential
to understand the basic pharmacokinetic parameters. All parameters are
considered, but only some of parameters are used in the model. Therefore,
we need to convert the estimated parameters to the other parameters after
fitting the specific pharmacokinetic model. This package is developed to help
this converting work. For more detailed explanation of pharmacokinetic
parameters, see "Gabrielsson and Weiner" (2007), "ISBN-10: 9197651001";
"Benet and Zia-Amirhosseini" (1995) <DOI: 10.1177/019262339502300203>;
"Mould and Upton" (2012) <DOI: 10.1038/psp.2012.4>;
"Mould and Upton" (2013) <DOI: 10.1038/psp.2013.14>.

OneComp_Volume_Clearance: Convert pharmacokinetic parameters for one compartment model

Description

Usage

Arguments

References

Examples