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PKconverter (version 1.5)

The Parameter Converter of the Pharmacokinetic Models

Description

Pharmacokinetics is the study of drug absorption, distribution, metabolism, and excretion. The pharmacokinetics model explains that how the drug concentration change as the drug moves through the different compartments of the body. For pharmacokinetic modeling and analysis, it is essential to understand the basic pharmacokinetic parameters. All parameters are considered, but only some of parameters are used in the model. Therefore, we need to convert the estimated parameters to the other parameters after fitting the specific pharmacokinetic model. This package is developed to help this converting work. For more detailed explanation of pharmacokinetic parameters, see "Gabrielsson and Weiner" (2007), "ISBN-10: 9197651001"; "Benet and Zia-Amirhosseini" (1995) ; "Mould and Upton" (2012) ; "Mould and Upton" (2013) .

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Version

Install

install.packages('PKconverter')

Monthly Downloads

204

Version

1.5

License

GPL (>= 2)

Maintainer

Eun-Kyung Lee

Last Published

February 6th, 2020

Functions in PKconverter (1.5)

OneComp_Volume_Clearance_HalfLife

Convert pharmacokinetic parameters for one compartment model
OneComp_Volume_Clearance

Convert pharmacokinetic parameters for one compartment model
ThreeComp_Volume_Exponent

Convert pharmacokinetic parameters for three compartment model
ThreeComp_Volume_Clearance_HalfLife

Convert pharmacokinetic parameters for three compartment model
TwoComp_Volume_Clearance

Convert pharmacokinetic parameters for two compartment model
TwoComp_Volume_Clearance_HalfLife

Convert pharmacokinetic parameters for two compartment model
OneComp_Volume_Exponent

Convert pharmacokinetic parameters for one compartment model
ThreeComp_Volume_Clearance

Convert pharmacokinetic parameters for three compartment model
TwoComp_Volume_Exponent

Convert pharmacokinetic parameters for two compartment model
TwoComp_Volume_RateConstant

Convert pharmacokinetic parameters for two compartment model
ThreeComp_Coefficient_Exponent

Convert pharmacokinetic parameters for three compartment model
OneComp_Volume_RateConstant

Convert pharmacokinetic parameters for one compartment model
PKconverterApp

Shiny App for converting the pharmacokinetic parameters
ThreeComp_Volume_RateConstant

Convert pharmacokinetic parameters for three compartment model
TwoComp_Coefficient_Exponent

Convert pharmacokinetic parameters for two compartment model
OneComp_Coefficient_Exponent

Convert pharmacokinetic parameters for one compartment model