PKconverter (version 1.5)

ThreeComp_Coefficient_Exponent: Convert pharmacokinetic parameters for three compartment model

Description

Calculate pharmacokinetic parameters with parameters (A, B, C, alpha, beta, and gamma) in two compartment model "Aexp(-alpha)+Bexp(-beta)+Cexp(-gamma)"

Usage

ThreeComp_Coefficient_Exponent(A,B,C,alpha,beta,gamma,A.sd=NA,
   B.sd=NA,C.sd=NA,alpha.sd=NA,beta.sd=NA,gamma.sd=NA,
   covar=c(AB=NA,AC=NA,Aalpha=NA,Abeta=NA,Agamma=NA,BC=NA,Balpha=NA,
   Bbeta=NA,Bgamma=NA,Calpha=NA,Cbeta=NA,Cgamma=NA,alphabeta=NA,
   alphagamma=NA,betagamma=NA),...)

Arguments

A

parameter in one compartment model "Aexp(-alpha)"

B

parameter in two compartment model "Aexp(-alpha)+Bexp(-beta)"

C

parameter in three compartment model "Aexp(-alpha)+Bexp(-beta)+Cexp(-gamma)"

alpha

parameter in one compartment model "Aexp(-alpha)"

beta

parameter in two compartment model "Aexp(-alpha)+Bexp(-beta)"

gamma

parameter in three compartment model "Aexp(-alpha)+Bexp(-beta)+Cexp(-gamma)"

A.sd

standard error of A

B.sd

standard error of B

C.sd

standard error of C

alpha.sd

standard error of alpha

beta.sd

standard error of beta

gamma.sd

standard error of gamma

covar

covariances among parameters

...

arguments to be passed to methods

References

http://www.nonmemcourse.com/convert.xls

Examples

# NOT RUN {
ThreeComp_Coefficient_Exponent(A=12.2,B=3.76,C=1.44,
alpha=0.870,beta=0.12,gamma=0.013, A.sd=0.2,B.sd=0.005,C.sd=0.0005,
alpha.sd=0.009,beta.sd=0.006,gamma.sd=0.00005)
# }