PKconverter (version 1.5)

TwoComp_Volume_Clearance: Convert pharmacokinetic parameters for two compartment model

Description

Calculate pharmacokinetic parameters with volume of distributions (V1 and V2) and clearances (Cl1 and Cl2)

Usage

TwoComp_Volume_Clearance(V1,V2,Cl1,Cl2,
                  V1.sd=NA,V2.sd=NA,Cl1.sd=NA,Cl2.sd=NA,
                  covar=c(V1V2=0,V1Cl1=0,V1Cl2=0,
                    V2Cl1=0,V2Cl2=0,Cl1Cl2=0),...)

Arguments

V1

The volume of distribution of compartment 1

V2

The volume of distribution of compartment 2

Cl1

Clearance from compartment 1

Cl2

Clearance from compartment 2

V1.sd

standard error of V1

V2.sd

standard error of V2

Cl1.sd

standard error of Cl1

Cl2.sd

standard error of Cl2

covar

covariances among parameters

...

arguments to be passed to methods

References

http://www.nonmemcourse.com/convert.xls

Examples

# NOT RUN {
TwoComp_Volume_Clearance(V1=5,V2=50,Cl1=3.5,Cl2=2.5,
         V1.sd=0.01,V2.sd=0.1,Cl1.sd=0.01,Cl2.sd=0.01)
# }