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Phase12Compare (version 1.5)

Simulates SPSO and Efftox Phase 12 Trials with Correlated Outcomes

Description

Simulating and conducting four phase 12 clinical trials with correlated binary bivariate outcomes described. Uses the 'Efftox' (efficacy and toxicity tradeoff, ) and SPSO (Semi-Parametric Stochastic Ordering) models with Utility and Desirability based objective functions for dose finding.

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Version

Install

install.packages('Phase12Compare')

Monthly Downloads

158

Version

1.5

License

GPL-2

Maintainer

Andrew Chapple

Last Published

July 31st, 2020

Functions in Phase12Compare (1.5)

Simulates trial replications from the SPSO model with desirability optimality function.

Returns the desireability value of a dose.

Generate binary bivariate data.

Obtains optimal dose level.

Assigns next patient cohort based on the SPSOP model with a Utility based objective function.

Assigns next patient cohort based on the Efftox model with a Utility based objective function.

GetEfftoxContour

Assigns next patient cohort based on the Efftox model with a Desirability based objective function.

Samples from the posterior of the utility based phase12 model.

Simulates trial replications from the Efftox model with utility optimality function.

SimEfftoxContour

Simulates trial replications from the Efftox model with desirability optimality function.

RunAdaptiveEffToxTrialCORR

Simulates utility based Efftox trials

RunAdaptiveEffToxTrialCORRCONTOUR

Simulates desirability based Efftox trials

Determines the optimal dose to assign the next patient cohort.

Determines the optimal dose to assign the next patient cohort.

Simulates trial replications from the SPSO model with desirability optimality function.

Returns prior dose-specific means and prior ESS for the SPSO model.

Assigns next patient cohort based on the SPSOP model with a Utility based objective function.