GETBIN

<p>Contains TRUE pi00,pi10, pi01, pi11 for each dose</p>

PVEC

<p>Generates binary bivariate data from a 2x2 matrix of probabilities.</p>

Simulating and conducting four phase 12 clinical trials with correlated binary bivariate outcomes described. Uses the 'Efftox' (efficacy and toxicity tradeoff, <https://biostatistics.mdanderson.org/SoftwareDownload/SingleSoftware/Index/2>) and SPSO (Semi-Parametric Stochastic Ordering) models with Utility and Desirability based objective functions for dose finding.

Andrew Chapple

GETBIN: Generate binary bivariate data.

Description

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