PriorCD-package

PriorCD

<p>This package implements methods to predict priorities of therapeutic drugs against interested cancer by combining drug functional similarity network and global network propagation algorithm. Besides, users can validate the prioritizing results and visualize the network structure of the resultant drugs.</p>

Prioritize candidate cancer drugs for drug repositioning based on the random walk with restart algorithm in a drug-drug functional similarity network. 1) We firstly constructed a drug-drug functional similarity network by integrating pathway activity and drug activity derived from the NCI-60 cancer cell lines. 2) Secondly, we calculated drug repurposing score according to a set of approved therapeutic drugs of interested cancer based on the random walk with restart algorithm in the drug-drug functional similarity network. 3) Finally, the permutation test was used to calculate the statistical significance level for the drug repurposing score.

Junwei Han

Prioritizing Cancer Drugs for Interested Cancer

PriorCD-package: Prioritizing cancer drugs for interested cancer

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