envData

drug.edgelist

drug.info

brc_candidates

breast_cancer

drug.fdr

drug.ic50

drug.r

mRNA_path

microRNA_path

priorlist

<p>Drug repurposing has become the focus of experts in drug development. In PriorCD, pathway activities and drug activities are combine to construct drug functional similarity network, and on which a global network propagation algorithm is applied. First, drug functional similarity network is constructed by the correlation and fdr of drug pairs. Then a global netwokr propagation (RWR) is performed on this network to prioritize candidates. Finally, ROC and network structure of the result can be browsed in PriorCD by getROC and getDDN functions.</p>

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Prioritize candidate cancer drugs for drug repositioning based on the random walk with restart algorithm in a drug-drug functional similarity network. 1) We firstly constructed a drug-drug functional similarity network by integrating pathway activity and drug activity derived from the NCI-60 cancer cell lines. 2) Secondly, we calculated drug repurposing score according to a set of approved therapeutic drugs of interested cancer based on the random walk with restart algorithm in the drug-drug functional similarity network. 3) Finally, the permutation test was used to calculate the statistical significance level for the drug repurposing score.

Junwei Han

PriorCD

Prioritizing Cancer Drugs for Interested Cancer

Jieyi Di

Baotong Zheng

envData function

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The variables in the environment include an example profile, a edgelist of our drug simiarity network, comprehensive drug information, restart drug set of breast cancer, candidate drugs of breast cancer, fdr of drug similarity network, correlation between drugs, mRNA and microRNA pathway activity profiles we've enriched. — envData

The variables in the environment include an example profile, a edgelist of our drug simiarity network, comprehensive drug information, restart drug set of breast cancer, candidate drugs of breast cancer, fdr of drug similarity network, correlation between drugs, mRNA and microRNA pathway activity profiles we've enriched.

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