RxODE (version 1.1.5)

.rxGenFoce: Generate FOCE without interaction

Description

Generate FOCE without interaction

Usage

.rxGenFoce(
  obj,
  predfn,
  pkpars = NULL,
  errfn = NULL,
  init = NULL,
  pred.minus.dv = TRUE,
  sum.prod = FALSE,
  optExpression = TRUE,
  promoteLinSens = TRUE,
  theta = FALSE,
  addProp = c("combined2", "combined1")
)

Arguments

obj

RxODE object

predfn

Prediction function

pkpars

Pk Pars function

errfn

Error function

init

Initialization parameters for scaling.

pred.minus.dv

Boolean stating if the FOCEi objective function is based on PRED-DV (like NONMEM). Default TRUE.

sum.prod

A boolean determining if RxODE should use more numerically stable sums/products.

optExpression

Optimize the model text for computer evaluation.

promoteLinSens

Promote solved linear compartment systems to sensitivity-based solutions.

theta

Calculate THETA derivatives instead of ETA derivatives. By default FALSE

addProp

one of "combined1" and "combined2"; These are the two forms of additive+proportional errors supported by monolix/nonmem:

combined1: transform(y)=transform(f)+(a+b*f^c)*eps

combined2: transform(y)=transform(f)+(a^2+b^2*f^(2c))*eps

Value

RxODE/symengine environment