gen_ITH_RD

Simulates observed alternate and reference read counts

Cluster user-supplied somatic read counts with corresponding allele-specific copy number and tumor purity to infer feasible underlying intra-tumor heterogeneity in terms of number of subclones, multiplicity, and allocation (Little et al. (2019) <doi:10.1186/s13073-019-0643-9>).

Paul Little

SMASH

Subclone Multiplicity Allocation and Somatic Heterogeneity

gen_ITH_RD function

<dl><dt>DATA</dt>
<dd>The output data.frame from <code>gen_subj_truth</code></dd>
<dt>RD</dt>
<dd>A positive integer for the mean read depth generated from 
the negative binomial distribution</dd></dl>

Arguments

gen_ITH_RD — gen_ITH_RD

<dl>

<dt>DATA</dt>
<dd>The output data.frame from <code>gen_subj_truth</code></dd>


<dt>RD</dt>
<dd>A positive integer for the mean read depth generated from 
the negative binomial distribution</dd>

</dl>

gen_ITH_RD: gen_ITH_RD

Description

Usage

Value

Arguments