SeqGSEA (version 1.12.0)

estiGeneNBstat: Calculate NB-statistics quantifying differential splicing for each gene

Description

Calculate NB-statistics quantifying differential splicing for each gene between two groups of samples compared. The results will be used for GSEA run (as DS-scores).

Usage

estiGeneNBstat(RCS)

Arguments

RCS

a ReadCountSet object after running estiExonNBstat.

Value

A ReadCountSet object with slot featureData_gene updated.

References

Weichen Wang, Zhiyi Qin, Zhixing Feng, Xi Wang and Xuegong Zhang (2013). Identifying differentially spliced genes from two groups of RNA-seq samples. Gene, 518(1):164-170.

See Also

estiExonNBstat

Examples

data(RCS_example, package="SeqGSEA")
RCS_example <- exonTestability(RCS_example, cutoff=5)
RCS_example <- estiExonNBstat(RCS_example)
RCS_example <- estiGeneNBstat(RCS_example)
head(RCS_example@featureData_gene)