limit_RML_binary

Calculate limit of RML for Poisson endpoints

internal

Design and analyze three-arm non-inferiority or superiority trials
which follow a gold-standard design, i.e. trials with an experimental treatment,
an active, and a placebo control. Method for the following distributions are implemented:
Poisson (Mielke and Munk (2009) <arXiv:0912.4169>), negative binomial (Muetze et al. (2016) <doi:10.1002/sim.6738>),
normal (Pigeot et al. (2003) <doi:10.1002/sim.1450>; Hasler et al. (2009) <doi:10.1002/sim.3052>),
binary (Friede and Kieser (2007) <doi:10.1002/sim.2543>), nonparametric (Muetze et al. (2017) <doi:10.1002/sim.7176>),
exponential (Mielke and Munk (2009) <arXiv:0912.4169>).

Tobias Muetze

ThreeArmedTrials

Design and Analysis of Clinical Non-Inferiority or Superiority
Trials with Active and Placebo Control

Tobias Mütze

Tim Friede

limit_RML_binary function

<dl><dt>pExp1</dt>
<dd>Experimental treatment group rate in the (assumed) alternative</dd>
<dt>pRef1</dt>
<dd>Experimental treatment group rate in the (assumed) alternative</dd>
<dt>pPla1</dt>
<dd>Experimental treatment group rate in the (assumed) alternative</dd>
<dt>Delta</dt>
<dd>Non-inferiority/Superiority margin</dd>
<dt>allocation</dt>
<dd>Sample size allocation</dd>
<dt>h</dt>
<dd>Function used when defining hypothesis</dd>
<dt>h_inv</dt>
<dd>Inverse function to h</dd></dl>

Arguments

limit_RML_binary — limit_RML_binary

<dl>

<dt>pExp1</dt>
<dd>Experimental treatment group rate in the (assumed) alternative</dd>


<dt>pRef1</dt>
<dd>Experimental treatment group rate in the (assumed) alternative</dd>


<dt>pPla1</dt>
<dd>Experimental treatment group rate in the (assumed) alternative</dd>


<dt>Delta</dt>
<dd>Non-inferiority/Superiority margin</dd>


<dt>allocation</dt>
<dd>Sample size allocation</dd>


<dt>h</dt>
<dd>Function used when defining hypothesis</dd>


<dt>h_inv</dt>
<dd>Inverse function to h</dd>

</dl>

limit_RML_binary: limit_RML_binary

Description

Usage

Arguments